|Families List Genes List|
Nanog genes have been detected in mammals and chick (Canon et al. 2006), but their origins are uncertain. The human NANOG gene has given rise to a tandem duplicate copy, but it is unclear if it is a pseudogene (hence denoted NANOGP1 by Booth and Holland 2004) or a functional gene (denoted NANOG2 by Hart et al. 2004). There are also 10 reverse-transcribed loci derived from NANOG in the human genome, denoted NANOGP2 to P11. Of these, NANOGP8 is the most recently generated and still has a complete open reading frame; it is expressed as RNA and protein in some cancer cells and may be functional in this setting (Zhang et al. 2006). There is limited evidence yet for function in normal cells or development. The human sequences are analysed by Booth and Holland (2004), chimpanzee comparisons made by Fairbanks and Maughan (2006), and functional analysis of the mouse Nanog gene described by Mitsui et al. (2003) and Chambers et al. (2003). The mouse gene was originally named Enk (Wang et al. 2003).|
Booth HAF, Holland PWH (2004) Genomics 84: 229-238.
CanonS, Herranz C, Manzanares, M (2006) Devel Dynamics 235: 2880-2894.
Chambers I. et al. (2003) Cell 113 :643-655.
Fairbanks DJ, Maughan PJ (2006) BMC Evol Biol. 6:12.
Hart AH, Hartley L, Ibrahim M, Robb L (2004) Devel Dynamics 230: 187-198.
Mitsui K et al. (2003) Cell 113:631-642.
Wang SH et al. (2003) Gene Expr Patterns 3:99-103.
Zhang J et al (2006) FEBS Journal 273: 1723-1730;
|Families List of Class ANTP :|