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ANTP Class
Families List  Genes List
Nk2.1 Family
The Nk2-1 gene family is named after the NK2 or vnd gene in Drosophila, even though this gene is not now considered part of the gene family (being placed in Nk2-2 family instead). The true Drosophila member of this gene family is scarecrow (scro). Scro is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-1 genes (NKX2-1, NKX2-4), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-1 gene. Nk2-1 genes are usually physically adjacent to Nk2-2 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Families List of Class ANTP :
HOXL subclass
NKL subclass
Loci in Nk2.1 of All back to top..
nkx2.1aNK2 homeobox 1aNk2.1Zebrafish 
nkx2.1bNK2 homeobox 1bNk2.1Zebrafish 
nkx2.1c Nk2.1Zebrafish 
ceh-24C. Elegans Homeobox 24Nk2.1Nematode 
ceh-27C. Elegans Homeobox 27Nk2.1Nematode 
Nkx2-1 Nk2.1Mouse 
Nkx2-4 Nk2.1Mouse 
NKX2-1NK2 homeobox 1Nk2.1Human 
NKX2-4NK2 homeobox 4Nk2.1Human 
nkx2-1NK2 homeobox 1Nk2.1Frog 
nkx2-1aNK2 homeobox 1-like aNk2.1Frog 
nkx2-1lbNK2 homeobox 1-like bNk2.1Frog 
nkx2-4NK2 homeobox 4 Nk2.1Frog 
NKX2-1NK2 homeobox 1Nk2.1Chicken