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ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Families List of Class ANTP :
HOXL subclass
NKL subclass
Loci in Nk2.2 of All back to top..
nkx2.2aNK2 transcription factor related 2aNk2.2Zebrafish 
nkx2.2bNK2 transcription factor related 2bNk2.2Zebrafish 
nkx2.9NK2 transcription factor related, locus 9Nk2.2Zebrafish 
ceh-22 C. Elegans Homeobox 22Nk2.2Nematode 
Nkx2-2 Nk2.2Mouse 
Nkx2-9 Nk2.2Mouse 
NKX2-2NK2 homeobox 2Nk2.2Human 
NKX2-8NK2 homeobox 8Nk2.2Human 
VndVentral nervous system defectiveNk2.2Honeybee 
vndventral nervous system defectiveNk2.2Fruitfly 
nkx2-2NK2 homeobox 2Nk2.2Frog 
nkx2-8NK2 homeobox 8Nk2.2Frog 
Nkx2-9 Nk2.2Chicken 
VndVentral nervous system defectiveNk2.2Beetle