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ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ANTP :
HOXL subclass
Cdx(22)Evx(17)Gbx(15)Gsx(13)Hox1(21)Hox2(13)Hox3(25)Hox4(24)Hox5(19)Hox6-8(55)
Hox9-13(15)(96)Meox(14)Mnx(15)Pdx(6)       
NKL subclass
Abox(5)Ankx(1)Barhl(16)Bari(4)Barx(10)Bsx(10)Dbx(15)Dlx(35)Emx(22)En(19)
Hhex(10)Hlx(9)Hx(1)Lbx(14)Lcx(1)Msx(22)Msxlx(3)Nanog(15)Nedx(5)Nk1(17)
Nk2.1(18)Nk2.2(15)Nk3(14)Nk4(19)Nk5/Hmx(25)Nk6(19)Nk7(4)Noto(10)Ro(5)Tlx(19)
Vax(12)Ventx(18)         
 
Loci in Nk2.2 of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
nkx2.2aNK2 transcription factor related 2aNk2.2Zebrafish 
nkx2.2bNK2 transcription factor related 2bNk2.2Zebrafish 
nkx2.9NK2 transcription factor related, locus 9Nk2.2Zebrafish 
ceh-22 C. Elegans Homeobox 22Nk2.2Nematode 
Nkx2-2 Nk2.2Mouse 
Nkx2-9 Nk2.2Mouse 
NKX2-2NK2 homeobox 2Nk2.2Human 
NKX2-8NK2 homeobox 8Nk2.2Human 
VndVentral nervous system defectiveNk2.2Honeybee 
vndventral nervous system defectiveNk2.2Fruitfly 
nkx2-2NK2 homeobox 2Nk2.2Frog 
nkx2-8NK2 homeobox 8Nk2.2Frog 
Nkx2-9 Nk2.2Chicken 
VndVentral nervous system defectiveNk2.2Beetle 
Nkx2-2Nkx2-2Nk2.2Amphioxus