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ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ANTP :
HOXL subclass
Cdx(1)Evx(2)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(1)Hox4(1)Hox5(1)Hox6-8(3)
Hox9-13(15)(7)Meox(1)Mnx(2)Pdx(1)       
NKL subclass
Abox(1)Ankx(1)Barhl(1)Bari(1)Barx(1)Bsx(1)Dbx(1)Dlx(1)Emx(3)En(1)
Hhex(1)Hlx(1)Hx(1)Lbx(1)Lcx(1)Msx(1)Msxlx(1)Nedx(2)Nk1(2)Nk2.1(1)
Nk2.2(1)Nk3(1)Nk4(1)Nk5/Hmx(1)Nk6(1)Nk7(1)Noto(1)Ro(1)Tlx(1)Vax(1)
Ventx(2)          
 
Loci in Nk2.2 of Amphioxus back to top..
Symbol/LocusNameFamilyOrganismRegulator
Nkx2-2Nkx2-2Nk2.2Amphioxus