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PRD Class
Families List  Genes List
Pax4/6 Family
The Pax4/6 genes, also known as Pax group IV, encodes proteins with a PRD domain and a complete PRD-type homeodomain. There are two genes in human, one in amphioxus and two clear examples in Drosophila (ey, toe). There are two additional related genes in Drosophila with a partial Pax domain which may be part of this gene family (eyg, toy); these are included here.

There is some confusion as to whether the Pax4/6 gene family this should be split into two gene families (Pax4 and Pax6), because invertebrate homologues generally group with PAX6 in phylogenetic analyses and not as an outgroup. However, this could be explained by extreme divergence of PAX4 causing violation of assumptions made in phylogenetic analysis.
 
Families List of Class PRD :
Alx(16)AprdA(1)AprdB(1)AprdC(1)AprdD(2)AprdE(1)Argfx(3)Arx(14)CG11294(3)
Dmbx(8)Dprx(8)Drgx(9)Dux(42)Esx(2)Gsc(14)Hbn(3)Hesx(5)Hopx(5)
Isx(5)Leutx(1)Mix(7)Nobox(5)Obox(36)Otp(12)Otx(24)Pax2/5/8(12)Pax3/7(24)
Pax4/6(24)Phox(17)Pitx(20)Prop(8)Prrx(14)Rax(14)Repo(4)Rhox(39)Sebox(3)
Shox(12)Tprx(5)Uncx(16)Vsx(18)      
 
Loci in Pax4/6 of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
pax4paired box 4Pax4/6Zebrafish 
Pax6-lPax6 likePax4/6Zebrafish 
pax6apaired box gene 6aPax4/6Zebrafish 
pax6bpaired box gene 6bPax4/6Zebrafish 
vab-3Variable ABnormal morphology 3Pax4/6Nematode 
Pax4 Pax4/6Mouse 
Pax6 Pax4/6Mouse 
PAX4paired box gene 4Pax4/6Human 
PAX6paired box 6Pax4/6Human 
EyEyelessPax4/6Honeybee 
EygEyegonePax4/6Honeybee 
ToyTwin of EyelessPax4/6Honeybee 
eyeyelessPax4/6Fruitfly 
eygeyegonePax4/6Fruitfly 
toetwin of eygPax4/6Fruitfly 
toytwin of eyelessPax4/6Fruitfly 
pax4lpax4 homeobox likePax4/6Frog 
pax6paired box 6Pax4/6Frog 
pax6lpaired box 6 likePax4/6Frog 
PAX6paired box gene 6Pax4/6Chicken 
EyEyelessPax4/6Beetle 
EygEyegonePax4/6Beetle 
ToyTwin of EyelessPax4/6Beetle 
Pax6Pax6Pax4/6Amphioxus