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TALE Class
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Tgif Family
The Tgif gene family (within the TALE class) is equivalent to the TGIF gene class of Bürglin and Mukherjee (2007). The Tgif gene family includes two human genes on autosomes and one gene with homologues on the X and Y chromosomes (TGIF2LX and TGIF2LY). The autosomal genes have generated a total of five pseudogenes although some of these are short and represent partial integrants of reverse transcribed mRNA (Holland et al. 2007). Two of the pseudogenes, TGIF2P2 and TGIF2P3 are very similar neighbouring loci that must have originated by tandem duplication after a single integration event. The sex-linked gene may also have arisen by retrotransposition (Blanco-Arias et al. 2002). There is one orthologue in amphioxus, and two tandemly arranged orthologues in Drosophila (achintya, achi and vismay, vis).

Reference(s):
Blanco-Arias P, Sargent CA, Affara NA (2002) Mamm Genome 13:463-468.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class TALE :
Irx(8)Meis(5)Mkx(1)Pbx(5)Pknox(2)Tgif(9)    
 
Loci in Tgif of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
TGIF1TGFB-induced factor homeobox 1TgifHuman 
TGIF1P1TGFB-induced factor homeobox 1 pseudogene 1TgifHuman 
TGIF2TGFB-induced factor 2 (TALE family homeobox)TgifHuman 
TGIF2LXTGFB-induced factor 2-like, X-linkedTgifHuman 
TGIF2LYTGFB-induced factor 2-like, Y-linkedTgifHuman 
TGIF2P1TGFB-induced factor homeobox 2 pseudogene 1TgifHuman 
TGIF2P2TGFB-induced factor homeobox 2 pseudogene 2TgifHuman 
TGIF2P3TGFB-induced factor homeobox 2 pseudogene 3TgifHuman 
TGIF2P4TGFB-induced factor homeobox 2 pseudogene 4TgifHuman