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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(1)Evx(2)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(1)Hox4(1)Hox5(1)Hox6-8(3)
Hox9-13(15)(7)Meox(1)Mnx(2)Pdx(1)       
NKL subclass
Abox(1)Ankx(1)Barhl(1)Bari(1)Barx(1)Bsx(1)Dbx(1)Dlx(1)Emx(3)En(1)
Hhex(1)Hlx(1)Hx(1)Lbx(1)Lcx(1)Msx(1)Msxlx(1)Nedx(2)Nk1(2)Nk2.1(1)
Nk2.2(1)Nk3(1)Nk4(1)Nk5/Hmx(1)Nk6(1)Nk7(1)Noto(1)Ro(1)Tlx(1)Vax(1)
Ventx(2)          
 
Loci in ANTP of Amphioxus back to top..
Symbol/LocusNameFamilyOrganismRegulator
AboxAboxAboxAmphioxus 
AnkxAnkxAnkxAmphioxus 
BarhBarhBarhlAmphioxus 
BariBariBariAmphioxus 
BarxBarxBarxAmphioxus 
BsxBsxBsxAmphioxus 
CdxCdxCdxAmphioxus 
CsxCsxNk4Amphioxus 
DbxDbxDbxAmphioxus 
DllDllDlxAmphioxus 
EmxaEmxaEmxAmphioxus 
EmxbEmxbEmxAmphioxus 
EmxcEmxcEmxAmphioxus 
EnEnEnAmphioxus 
EvxaEvxaEvxAmphioxus 
EvxbEvxbEvxAmphioxus 
GbxGbxGbxAmphioxus 
GsxGsxGsxAmphioxus 
HhexHhexHhexAmphioxus 
HlxHlxHlxAmphioxus 
HmxHmxNk5/HmxAmphioxus 
Hox1Hox1Hox1Amphioxus 
Hox10Hox10Hox9-13(15)Amphioxus 
Hox11Hox11Hox9-13(15)Amphioxus 
Hox12Hox12Hox9-13(15)Amphioxus 
Hox13Hox13Hox9-13(15)Amphioxus 
Hox14Hox14Hox9-13(15)Amphioxus 
Hox15Hox15Hox9-13(15)Amphioxus 
Hox2Hox2Hox2Amphioxus 
Hox3Hox3Hox3Amphioxus 
Hox4Hox4Hox4Amphioxus 
Hox5Hox5Hox5Amphioxus 
Hox6Hox6Hox6-8Amphioxus 
Hox7Hox7Hox6-8Amphioxus 
Hox8Hox8Hox6-8Amphioxus 
Hox9Hox9Hox9-13(15)Amphioxus 
HxHxHxAmphioxus 
LbxLbxLbxAmphioxus 
LcxLcxLcxAmphioxus 
MnxaMnxaMnxAmphioxus 
MnxbMnxbMnxAmphioxus 
MoxMoxMeoxAmphioxus 
MsxMsxMsxAmphioxus 
MsxlxMsxlxMsxlxAmphioxus 
NedxaNedxaNedxAmphioxus 
NedxbNedxbNedxAmphioxus 
Nkx1aNkx1aNk1Amphioxus 
Nkx1bNkx1bNk1Amphioxus 
Nkx2-1Nkx2-1Nk2.1Amphioxus 
Nkx2-2Nkx2-2Nk2.2Amphioxus 
Nkx3Nkx3Nk3Amphioxus 
Nkx6Nkx6Nk6Amphioxus 
Nkx7Nkx7Nk7Amphioxus 
NotNotNotoAmphioxus 
RoRoRoAmphioxus 
TlxTlxTlxAmphioxus 
VaxVaxVaxAmphioxus 
Vent1Vent1VentxAmphioxus 
Vent2Vent2VentxAmphioxus 
XloxXloxPdxAmphioxus