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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(4)Evx(2)Gbx(2)Gsx(1)Hox1(3)Hox2(1)Hox3(3)Hox4(3)Hox5(2)Hox6-8(6)
Hox9-13(15)(13)Meox(2)Mnx(2)Pdx(1)       
NKL subclass
Barx(1)Bsx(1)Dbx(2)Dlx(4)Emx(2)En(1)Hhex(1)Hlx(1)Lbx(1)Msx(2)
Nk1(2)Nk2.1(1)Nk2.2(1)Nk4(2)Nk5/Hmx(5)Nk6(2)Noto(2)Tlx(2)Vax(1)Ventx(1)
 
Loci in ANTP of Chicken back to top..
Symbol/LocusNameFamilyOrganismRegulator
BARX2BARX homeobox 2BarxChicken 
BSXbrain-specific homeoboxBsxChicken 
CDX1caudal type homeobox 1CdxChicken 
CDX2caudal type homeobox 2CdxChicken 
CDX4caudal type homeobox 4CdxChicken 
CDX4-2caudal type homeobox 4 duplicationCdxChicken 
CNOT2CCR4-NOT transcription complex, subunit 2NotoChicken 
DBX1developing brain homeobox 1DbxChicken 
DBX2developing brain homeobox 2DbxChicken 
DLX1distal-less homeobox 1DlxChicken 
Dlx3-lDlx3 likeDlxChicken 
DLX5distal-less homeobox 5DlxChicken 
DLX6distal-less homeobox 6DlxChicken 
EMX1empty spiracles homeobox 1EmxChicken 
EMX2empty spiracles homeobox 2EmxChicken 
EN1engrailed homeobox 1EnChicken 
EVX1even-skipped homeobox 1EvxChicken 
EVX2even-skipped homeobox 2EvxChicken 
GBX1gastrulation brain homeobox 1GbxChicken 
GBX2gastrulation brain homeobox 2GbxChicken 
gga_chr02.1possibly homeobox A5Hox5Chicken 
gga_chr03.1possibly HLXHlxChicken 
GNOT1Gnot1 homeodomain proteinNotoChicken 
HHEXhematopoietically expressed homeoboxHhexChicken 
HMX1H6 family homeobox 1Nk5/HmxChicken 
HMX2H6 family homeobox 2Nk5/HmxChicken 
HMX2-likesimilar to homeo box (H6 family) 2Nk5/HmxChicken 
HMX3H6 family homeobox 3Nk5/HmxChicken 
Hox-10homeobox -10Hox9-13(15)Chicken 
Hox-6homeobox -6Hox6-8Chicken 
Hox-7homeobox -7Hox6-8Chicken 
HOXA1homeobox A1Hox1Chickengga-mir-181a
HOXA10homeobox A10Hox9-13(15)Chicken 
HOXA11homeobox A11Hox9-13(15)Chicken 
HOXA3homeobox A3Hox3Chicken 
HOXA4homeobox A4Hox4Chicken 
HOXA6homeobox A6Hox6-8Chicken 
HOXA7homeobox A7Hox6-8Chicken 
HOXA9homeobox A9Hox9-13(15)Chicken 
HOXB1homeobox B1Hox1Chicken 
HOXB13homeobox B13Hox9-13(15)Chicken 
HOXB2homeobox B2Hox2Chicken 
HOXB3homeobox B3Hox3Chicken 
HOXB5homeobox B5Hox5Chicken 
HOXB8homeobox B8Hox6-8Chicken 
HOXB9homeobox B9Hox9-13(15)Chicken 
Hoxc11homeobox c11Hox9-13(15)Chicken 
Hoxc13homeobox C13Hox9-13(15)Chicken 
Hoxc4homeobox C4Hox4Chicken 
Hoxc9Homeobox C10Hox9-13(15)Chicken 
HOXD1homeobox D1Hox1Chicken 
HOXD11homeobox D11Hox9-13(15)Chicken 
HOXD12homeobox D12Hox9-13(15)Chicken 
HOXD13homeobox D13Hox9-13(15)Chicken 
HOXD3homeobox D3Hox3Chicken 
HOXD4homeobox D4Hox4Chicken 
HOXD8homeobox D8Hox6-8Chicken 
Lbx-lLbx likeLbxChicken 
LOC429994hypothetical LOC429994GsxChicken 
LOC771682similar to Hoxb-13Hox9-13(15)Chicken 
MEOX1mesenchyme homeobox 1MeoxChicken 
MEOX2mesenchyme homeobox 2MeoxChicken 
MNR2homeodomain proteinMnxChicken 
MNX1motor neuron and pancreas homeobox 1MnxChicken 
MSX1msh homeobox 1MsxChicken 
MSX2msh homeobox 2MsxChicken 
NKX1-1NK1 homeobox 1Nk1Chicken 
NKX1-2 Nk1Chicken 
NKX2-1NK2 homeobox 1Nk2.1Chicken 
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)Nk4Chicken 
NKX2-6NK2 transcription factor related, locus 6Nk4Chicken 
Nkx2-9 Nk2.2Chicken 
NKX6-2NK6 homeobox 2Nk6Chicken 
NKX6-3NK6 transcription factor related, locus 3Nk6Chicken 
PDX1pancreatic and duodenal homeobox 1PdxChicken 
SOHO-1sensory organ homeobox protein SOHoNk5/HmxChicken 
TLX1T-cell leukemia homeobox 1TlxChicken 
TLX3T-cell leukemia homeobox 3TlxChicken 
VAX1ventral anterior homeobox 1VaxChicken 
VENTXVENT homeobox homolog (Xenopus laevis)VentxChicken