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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(2)Gbx(3)Gsx(2)Hox1(3)Hox2(2)Hox3(4)Hox4(4)Hox5(3)Hox6-8(8)
Hox9-13(15)(15)Meox(1)Mnx(2)Pdx(1)       
NKL subclass
Barhl(2)Barx(2)Bsx(1)Dbx(2)Dlx(6)Emx(4)En(2)Hhex(2)Hlx(1)Lbx(1)
Msx(2)Nk1(3)Nk2.1(4)Nk2.2(2)Nk3(3)Nk4(3)Nk5/Hmx(5)Nk6(3)Noto(1)Tlx(3)
Vax(2)Ventx(6)         
 
Loci in ANTP of Frog back to top..
Symbol/LocusNameFamilyOrganismRegulator
barhl1BarH-like homeobox 1 BarhlFrog 
barhl2BarH-like homeobox 2 BarhlFrog 
barx1BARX homeobox 1BarxFrog 
barx2BARX homeobox 2 BarxFrog 
bsxbrain-specific homeoboxBsxFrog 
cdx1 caudal type homeobox 1CdxFrog 
cdx2caudal type homeobox 2CdxFrog 
cdx4caudal type homeobox 4 CdxFrog 
dbx1developing brain homeobox 1 DbxFrog 
dbx2developing brain homeobox 2 DbxFrog 
dlx1distal-less homeobox 1 DlxFrog 
dlx2distal-less homeobox 2 DlxFrog 
dlx3distal-less homeobox 3DlxFrog 
dlx4distal-less homeobox 4DlxFrog 
dlx5distal-less homeobox 5 DlxFrog 
dlx6distal-less homeobox 6DlxFrog 
emx1empty spiracles homeobox 1EmxFrog 
emx1-lempty spiracles homeobox 1 likeEmxFrog 
emx1.2empty spiracles homeobox 1, gene 2EmxFrog 
emx2empty spiracles homeobox 2 EmxFrog 
en1engrailed homeobox 1EnFrog 
en2engrailed homeobox 2 EnFrog 
evx1even-skipped homeobox 1EvxFrog 
evx2even-skipped homeobox 2EvxFrog 
gbx1gastrulation brain homeobox 1GbxFrog 
gbx2.1gastrulation brain homeobox 2, gene 1 GbxFrog 
gbx2.2gastrulation brain homeobox 2, gene 2GbxFrog 
gsx1GS homeobox 1GsxFrog 
gsx2GS homeobox 2GsxFrog 
hhexhematopoietically expressed homeoboxHhexFrog 
hhex-lhematopoietically expressed homeobox likeHhexFrog 
hlx1H2.0-like homeobox HlxFrog 
hmx1H6 family homeobox 1Nk5/HmxFrog 
hmx2H6 family homeobox 2Nk5/HmxFrog 
hmx3H6 family homeobox 3Nk5/HmxFrog 
hmx4H6 family homeobox 4Nk5/HmxFrog 
hmx4bH6 family homeobox 4bNk5/HmxFrog 
hoxa1homeobox A1Hox1Frog 
hoxa10homeobox A10Hox9-13(15)Frog 
hoxa11homeobox A11 Hox9-13(15)Frog 
hoxa13homeobox A13 Hox9-13(15)Frog 
hoxa2homeobox A2Hox2Frog 
hoxa3homeobox A3 Hox3Frog 
Hoxa4homeobox A4Hox4Frog 
hoxa5homeobox A5 Hox5Frog 
hoxa6homeobox A6Hox6-8Frog 
hoxa7homeobox A7 Hox6-8Frog 
hoxa9homeobox A9 Hox9-13(15)Frog 
hoxb1homeobox B1 Hox1Frog 
hoxb10homeobox B9 Hox9-13(15)Frog 
hoxb2homeobox B2Hox2Frog 
hoxb3homeobox B3Hox3Frog 
hoxb4homeobox B4Hox4Frog 
hoxb5homeobox B5 Hox5Frog 
hoxb6homeobox B6Hox6-8Frog 
hoxb7homeobox B7 Hox6-8Frog 
hoxb8homeobox B8 Hox6-8Frog 
hoxb9homeobox B9 Hox9-13(15)Frog 
hoxc10homeobox C10 Hox9-13(15)Frog 
hoxc11homeobox C11Hox9-13(15)Frog 
hoxc12homeobox C12 Hox9-13(15)Frog 
hoxc13homeobox C13 Hox9-13(15)Frog 
hoxc3homeobox C3Hox3Frog 
hoxc4homeobox C4 Hox4Frog 
hoxc5homeobox C5 Hox5Frog 
hoxc6 homeobox C6Hox6-8Frog 
hoxc8homeobox C8Hox6-8Frog 
hoxc9homeobox C9 Hox9-13(15)Frog 
hoxd1homeobox D1 Hox1Frog 
hoxd10homeobox D10 Hox9-13(15)Frog 
hoxd11homeobox D11Hox9-13(15)Frog 
hoxd13homeobox D13Hox9-13(15)Frog 
hoxd3homeobox D3Hox3Frog 
hoxd4homeobox D4Hox4Frog 
hoxd8homeobox D8Hox6-8Frog 
hoxd9homeobox D9 Hox9-13(15)Frog 
lbx1ladybird homeobox 1LbxFrog 
meox2mesenchyme homeobox 2 MeoxFrog 
mnx1motor neuron and pancreas homeobox 1MnxFrog 
mnx1-lmotor neuron and pancreas homeobox 1 likeMnxFrog 
msx1msh homeobox 1MsxFrog 
msx2msh homeobox 2MsxFrog 
nkx1-2NK1 homeobox 2Nk1Frog 
nkx1-2laNK1 transcription factor related 2-like aNk1Frog 
nkx1-2lbNK1 transcription factor related 2-like bNk1Frog 
nkx2-1NK2 homeobox 1Nk2.1Frog 
nkx2-1aNK2 homeobox 1-like aNk2.1Frog 
nkx2-1lbNK2 homeobox 1-like bNk2.1Frog 
nkx2-2NK2 homeobox 2Nk2.2Frog 
nkx2-3NK2 transcription factor related, locus 3Nk4Frog 
nkx2-4NK2 homeobox 4 Nk2.1Frog 
nkx2-5NK2 transcription factor related, locus 5Nk4Frog 
nkx2-6NK2 transcription factor related, locus 6Nk4Frog 
nkx2-8NK2 homeobox 8Nk2.2Frog 
nkx3-1NK3 homeobox 1Nk3Frog 
nkx3-2NK3 homeobox 2 Nk3Frog 
nkx3-2lNK3 homeobox 2 likeNk3Frog 
nkx6-1NK6 homeobox 1 Nk6Frog 
nkx6-2NK6 homeobox 2 Nk6Frog 
nkx6-3NK6 homeobox 3 Nk6Frog 
notnotochord homeoboxNotoFrog 
pdx1pancreatic and duodenal homeobox 1PdxFrog 
tlx1T-cell leukemia homeobox 1 TlxFrog 
tlx2T-cell leukemia homeobox 2TlxFrog 
tlx3T-cell leukemia homeobox 3TlxFrog 
vax1ventral anterior homeobox 1VaxFrog 
vax2ventral anterior homeobox 2 VaxFrog 
ventx1.1VENT homeobox 1, gene 1VentxFrog 
ventx1.2VENT homeobox 1, gene 2VentxFrog 
ventx2.1VENT homeobox 2, gene 1VentxFrog 
ventx2.2VENT homeobox 2, gene 2VentxFrog 
ventx3.1VENT homeobox 3, gene 1VentxFrog 
ventx3.2VENT homeobox 3, gene 2VentxFrog