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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(1)Evx(1)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(3)Hox4(1)Hox5(1)Hox6-8(4)
Hox9-13(15)(1)Meox(1)Mnx(1)        
NKL subclass
Abox(1)Barhl(2)Bari(1)Bsx(1)Dbx(1)Dlx(1)Emx(2)En(2)Hhex(1)Hlx(1)
Lbx(2)Msx(1)Msxlx(1)Nedx(1)Nk1(1)Nk2.1(1)Nk2.2(1)Nk3(1)Nk4(1)Nk5/Hmx(1)
Nk6(1)Nk7(1)Noto(1)Ro(1)Tlx(1)      
 
Loci in ANTP of Fruitfly back to top..
Symbol/LocusNameFamilyOrganismRegulator
abd-Aabdominal AHox6-8Fruitfly 
Abd-BAbdominal BHox9-13(15)Fruitfly 
AntpAntennapediaHox6-8Fruitfly 
B-H1BarH1BarhlFruitfly 
B-H2BarH2BarhlFruitfly 
bapbagpipeNk3Fruitfly 
bcdbicoidHox3Fruitfly 
bshbrain-specific homeoboxBsxFruitfly 
btnbuttonlessMeoxFruitfly 
C15C15TlxFruitfly 
cadcaudalCdxFruitfly 
CG11085CG11085BariFruitfly 
CG12361CG12361DbxFruitfly 
CG13424CG13424NedxFruitfly 
CG15696CG15696MsxlxFruitfly 
CG18599CG18599NotoFruitfly 
CG34031CG34031AboxFruitfly 
CG7056CG7056HhexFruitfly 
DfdDeformedHox4Fruitfly 
DllDistal-lessDlxFruitfly 
DrDropMsxFruitfly 
E5E5EmxFruitfly 
emsempty spiraclesEmxFruitfly 
enengrailedEnFruitfly 
eveeven-skippedEvxFruitfly 
exexextra-extraMnxFruitfly 
ftzfushi tarazuHox6-8Fruitfly 
H2.0Homeodomain protein 2.0HlxFruitfly 
HGTXHGTXNk6Fruitfly 
HmxH6-like-homeoboxNk5/HmxFruitfly 
indintermediate neuroblasts defectiveGsxFruitfly 
invinvectedEnFruitfly 
lablabialHox1Fruitfly 
lbeladybird earlyLbxFruitfly 
lblladybird lateLbxFruitfly 
NK7.1NK7.1Nk7Fruitfly 
pbproboscipediaHox2Fruitfly 
roroughRoFruitfly 
ScrSex combs reducedHox5Fruitfly 
scroscarecrowNk2.1Fruitfly 
slouslouchNk1Fruitfly 
tintinmanNk4Fruitfly 
UbxUltrabithoraxHox6-8Fruitfly 
unpgunpluggedGbxFruitfly 
vndventral nervous system defectiveNk2.2Fruitfly 
zenzerknuelltHox3Fruitfly 
zen2zerknullt-relatedHox3Fruitfly