Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(1)Evx(1)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(1)Hox4(1)Hox5(1)Hox6-8(4)
Hox9-13(15)(1)Meox(1)Mnx(1)        
NKL subclass
Abox(1)Barhl(1)Bari(1)Bsx(1)Dbx(1)Dlx(1)Emx(1)En(2)Hlx(1)Lbx(1)
Msx(2)Nedx(1)Nk1(1)Nk2.1(1)Nk2.2(1)Nk3(1)Nk4(1)Nk6(1)Noto(1)Ro(1)
Tlx(1)          
 
Loci in ANTP of Honeybee back to top..
Symbol/LocusNameFamilyOrganismRegulator
Abd-AAbdominal AHox6-8Honeybee 
Abd-BAbdominal BHox9-13(15)Honeybee 
AboxAbsent from Olfactores HomeoboxAboxHoneybee 
AntpAntennapediaHox6-8Honeybee 
B-HBarHBarhlHoneybee 
BapBagpipeNk3Honeybee 
BariBariBariHoneybee 
BshBrain-specific homeoboxBsxHoneybee 
BtnButtonlessMeoxHoneybee 
C15C15TlxHoneybee 
CadCaudalCdxHoneybee 
DbxDeveloping brain homeoboxDbxHoneybee 
DfdDeformedHox4Honeybee 
DllDistallessDlxHoneybee 
Dr1Drop1MsxHoneybee 
Dr2Drop2MsxHoneybee 
EmsEmpty spiraclesEmxHoneybee 
EnEngrailedEnHoneybee 
EveEven skippedEvxHoneybee 
ExexExtra extraMnxHoneybee 
FtzFushi TarazuHox6-8Honeybee 
H2.0H2.0HlxHoneybee 
HgtxHgtxNk6Honeybee 
IndIntermediate neuroblasts defectiveGsxHoneybee 
InvInvectedEnHoneybee 
LabLabialHox1Honeybee 
LbxLadybirdLbxHoneybee 
NedxNext to distalless homeoboxNedxHoneybee 
NotNotNotoHoneybee 
PbProboscipediaHox2Honeybee 
RoRoughbRoHoneybee 
ScrSex combs reducedHox5Honeybee 
ScroScarecrowNk2.1Honeybee 
SlouSlouchNk1Honeybee 
TinTinmanNk4Honeybee 
UbxUltrabithoraxHox6-8Honeybee 
UnpgUnpluggedGbxHoneybee 
VndVentral nervous system defectiveNk2.2Honeybee 
ZenZerknuelltHox3Honeybee