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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(2)Gbx(2)Gsx(2)Hox1(3)Hox2(2)Hox3(3)Hox4(4)Hox5(3)Hox6-8(8)
Hox9-13(15)(16)Meox(2)Mnx(1)Pdx(1)       
NKL subclass
Barhl(2)Barx(2)Bsx(1)Dbx(2)Dlx(6)Emx(2)En(2)Hhex(1)Hlx(1)Lbx(2)
Msx(3)Nanog(12)Nk1(2)Nk2.1(2)Nk2.2(2)Nk3(2)Nk4(3)Nk5/Hmx(3)Nk6(3)Noto(1)
Tlx(3)Vax(2)Ventx(8)        
 
Loci in ANTP of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
BARHL1BarH-like homeobox 1BarhlHuman 
BARHL2BarH-like homeobox 2BarhlHuman 
BARX1BARX homeobox 1BarxHuman 
BARX2BARX homeobox 2BarxHuman 
BSXbrain specific homeoboxBsxHuman 
CDX1caudal type homeobox 1CdxHuman 
CDX2caudal type homeobox 2CdxHumanhsa-mir-9
CDX4caudal type homeobox 4CdxHuman 
DBX1developing brain homeobox 1DbxHuman 
DBX2developing brain homeobox 2DbxHuman 
DLX1distal-less homeobox 1DlxHuman 
DLX2distal-less homeobox 2DlxHuman 
DLX3distal-less homeobox 3DlxHuman 
DLX4distal-less homeobox 4DlxHuman 
DLX5distal-less homeobox 5DlxHuman 
DLX6distal-less homeobox 6DlxHuman 
EMX1empty spiracles homolog 1EmxHuman 
EMX2empty spiracles homolog 2EmxHuman 
EN1engrailed homeobox 1EnHuman 
EN2engrailed homeobox 2EnHuman 
EVX1even-skipped homeobox homolog 1EvxHuman 
EVX2even-skipped homeobox homolog 2EvxHuman 
GBX1gastrulation brain homeobox 1GbxHuman 
GBX2gastrulation brain homeobox 2GbxHuman 
GSX1GS homeobox 1GsxHuman 
GSX2GS homeobox 2GsxHuman 
HHEXhematopoietically expressed homeoboxHhexHuman 
HLXH2.0-like homeobox 1HlxHuman 
HMX1H6 family homeobox 1Nk5/HmxHuman 
HMX2H6 family homeobox 2Nk5/HmxHuman 
HMX3H6 family homeobox 3Nk5/HmxHuman 
HOXA1homeobox A1Hox1Human 
HOXA10homeobox A10Hox9-13(15)Human 
HOXA11homeobox A11Hox9-13(15)Human 
HOXA13homeobox A13Hox9-13(15)Human 
HOXA2homeobox A2Hox2Human 
HOXA3homeobox A3Hox3Human 
HOXA4homeobox A4Hox4Human 
HOXA5homeobox A5Hox5Humanhsa-mir-130a
HOXA6homeobox A6Hox6-8Human 
HOXA7homeobox A7Hox6-8Humanhsa-mir-196
HOXA9homeobox A9Hox9-13(15)Humanhsa-mir-196a; hsa-mir-210
HOXB1homeobox B1Hox1Human 
HOXB13homeobox B13Hox9-13(15)Human 
HOXB2homeobox B2Hox2Human 
HOXB3homeobox B3Hox3Human 
HOXB4homeobox B4Hox4Human 
HOXB5homeobox B5Hox5Humanhsa-miR-221
HOXB6homeobox B6Hox6-8Human 
HOXB7homeobox B7Hox6-8Human 
HOXB8homeobox B8Hox6-8Humanhsa-mir-196a
HOXB9homeobox B9Hox9-13(15)Human 
HOXC10homeobox C10Hox9-13(15)Human 
HOXC11homeobox C11Hox9-13(15)Human 
HOXC12homeobox C12Hox9-13(15)Human 
HOXC13homeobox C13Hox9-13(15)Human 
HOXC4homeobox C4Hox4Human 
HOXC5homeobox C5Hox5Human 
HOXC6homeobox C6Hox6-8Human 
HOXC8homeobox C8Hox6-8Humanhsa-mir-196
HOXC9homeobox C9Hox9-13(15)Human 
HOXD1homeobox D1Hox1Human 
HOXD10homeobox D10Hox9-13(15)Humanhsa-miR-10b
HOXD11homeobox D11Hox9-13(15)Human 
HOXD12homeobox D12Hox9-13(15)Human 
HOXD13homeobox D13Hox9-13(15)Human 
HOXD3homeobox D3Hox3Human 
HOXD4homeobox D4Hox4Humanhsa-mir-10a
HOXD8homeobox D8Hox6-8Humanhsa-mir-196
HOXD9homeobox D9Hox9-13(15)Human 
LBX1ladybird homeobox 1LbxHuman 
LBX2ladybird homeobox 2LbxHuman 
MEOX1mesenchyme homeobox 1MeoxHuman 
MEOX2mesenchyme homeobox 2MeoxHumanhsa-mir-130a; hsa-mir-301a
MNX1motor neuron and pancreas homeobox 1MnxHuman 
MSX1msh homeobox 1MsxHuman 
MSX2msh homeobox 2MsxHuman 
MSX2P1msh homeobox 2 pseudogeneMsxHuman 
NANOGNanog homeoboxNanogHuman 
NANOGP1Nanog homeobox pseudogene 1NanogHuman 
NANOGP10Nanog homeobox pseudogene 10NanogHuman 
NANOGP11Nanog homeobox pseudogene 11NanogHuman 
NANOGP2Nanog homeobox pseudogene 2NanogHuman 
NANOGP3Nanog homeobox pseudogene 3NanogHuman 
NANOGP4Nanog homeobox pseudogene 4NanogHuman 
NANOGP5Nanog homeobox pseudogene 5NanogHuman 
NANOGP6Nanog homeobox pseudogene 6NanogHuman 
NANOGP7Nanog homeobox pseudogene 7NanogHuman 
NANOGP8Nanog homeobox pseudogene 8NanogHuman 
NANOGP9Nanog homeobox pseudogene 9NanogHuman 
NKX1-1NK1 homeobox 1Nk1Human 
NKX1-2NK1 homeobox 2Nk1Human 
NKX2-1NK2 homeobox 1Nk2.1Human 
NKX2-2NK2 homeobox 2Nk2.2Human 
NKX2-3NK2 homeobox 3Nk4Human 
NKX2-4NK2 homeobox 4Nk2.1Human 
NKX2-5NK2 homeobox 5Nk4Human 
NKX2-6NK2 homeobox 6Nk4Human 
NKX2-8NK2 homeobox 8Nk2.2Human 
NKX3-1NK3 homeobox 1Nk3Human 
NKX3-2Nk3 homeobox 2Nk3Human 
NKX6-1NK6 transcription factor related, locus 1 (Drosophila)Nk6Human 
NKX6-2NK6 transcription factor related, locus 2 (Drosophila)Nk6Human 
NKX6-3NK6 transcription factor related, locus 3 (Drosophila)Nk6Human 
NOTOnotochord homologNotoHuman 
PDX1pancreatic and duodenal homeobox1PdxHuman 
TLX1T-cell leukemia homeobox 1TlxHuman 
TLX2T-cell leukemia homeobox 2TlxHuman 
TLX3T-cell leukemia homeobox 3TlxHuman 
VAX1ventral anterior homeobox 1VaxHuman 
VAX2ventral anterior homeobox 2VaxHuman 
VENTXVENT homeoboxVentxHuman 
VENTXP1VENT homeobox pseudogene 1VentxHuman 
VENTXP2VENT homeobox pseudogene 2VentxHuman 
VENTXP3VENT homeobox pseudogene 3VentxHuman 
VENTXP4VENT homeobox pseudogene 4VentxHuman 
VENTXP5VENT homeobox pseudogene 5VentxHuman 
VENTXP6VENT homeobox pseudogene 6VentxHuman 
VENTXP7VENT homeobox pseudogene 7VentxHuman