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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(2)Gbx(2)Gsx(2)Hox1(3)Hox2(2)Hox3(3)Hox4(4)Hox5(3)Hox6-8(8)
Hox9-13(15)(16)Meox(2)Mnx(1)Pdx(1)       
NKL subclass
Barhl(2)Barx(2)Bsx(1)Dbx(2)Dlx(6)Emx(2)En(2)Hhex(1)Hlx(1)Lbx(2)
Msx(3)Nanog(3)Nk1(2)Nk2.1(2)Nk2.2(2)Nk3(2)Nk4(3)Nk5/Hmx(3)Nk6(3)Noto(1)
Tlx(3)Vax(2)         
 
Loci in ANTP of Mouse back to top..
Symbol/LocusNameFamilyOrganismRegulator
Barhl1 BarhlMousemmu-mir-203; mmu-mir-7a
Barhl2 BarhlMouse 
Barx1 BarxMouse 
Barx2 BarxMouse 
Bsx BsxMouse 
Cdx1 CdxMouse 
Cdx2 CdxMouse 
Cdx4 CdxMouse 
Dbx1 DbxMouse 
Dbx2 DbxMouse 
Dlx1 DlxMouse 
Dlx2 DlxMouse 
Dlx3 DlxMouse 
Dlx4 DlxMouse 
Dlx5 DlxMousemmu-mir-141; mmu-mir-200a
Dlx6 DlxMouse 
Emx1 EmxMouse 
Emx2 EmxMouse 
En1 EnMouse 
En2 EnMouse 
Evx1 EvxMouse 
Evx2 EvxMouse 
Gbx1 GbxMouse 
Gbx2 GbxMouse 
Gsx1 GsxMouse 
Gsx2 GsxMouse 
Hhex HhexMouse 
Hlx HlxMouse 
Hmx1 Nk5/HmxMouse 
Hmx2 Nk5/HmxMouse 
Hmx3 Nk5/HmxMouse 
Hoxa1 Hox1Mouse 
Hoxa10 Hox9-13(15)Mouse 
Hoxa11 Hox9-13(15)Mousemmu-mir-181a; mmu-mir-181b
Hoxa13 Hox9-13(15)Mouse 
Hoxa2 Hox2Mousemmu-mir-3960
Hoxa3 Hox3Mouse 
Hoxa4 Hox4Mouse 
Hoxa5 Hox5Mouse 
Hoxa6 Hox6-8Mouse 
Hoxa7 Hox6-8Mouse 
Hoxa9 Hox9-13(15)Mousemmu-mir-126
Hoxb1 Hox1Mouse 
Hoxb13 Hox9-13(15)Mouse 
Hoxb2 Hox2Mouse 
Hoxb3 Hox3Mouse 
Hoxb4 Hox4Mouse 
Hoxb5 Hox5Mouse 
Hoxb6 Hox6-8Mouse 
Hoxb7 Hox6-8Mouse 
Hoxb8 Hox6-8Mousemmu-mir-196
Hoxb9 Hox9-13(15)Mouse 
Hoxc10 Hox9-13(15)Mouse 
Hoxc11 Hox9-13(15)Mouse 
Hoxc12 Hox9-13(15)Mouse 
Hoxc13 Hox9-13(15)Mouse 
Hoxc4 Hox4Mouse 
Hoxc5 Hox5Mouse 
Hoxc6 Hox6-8Mouse 
Hoxc8 Hox6-8Mouse 
Hoxc9 Hox9-13(15)Mouse 
Hoxd1 Hox1Mouse 
Hoxd10 Hox9-13(15)Mouse 
Hoxd11 Hox9-13(15)Mouse 
Hoxd12 Hox9-13(15)Mouse 
Hoxd13 Hox9-13(15)Mouse 
Hoxd3 Hox3Mouse 
Hoxd4 Hox4Mouse 
Hoxd8 Hox6-8Mouse 
Hoxd9 Hox9-13(15)Mouse 
Lbx1 LbxMouse 
Lbx2 LbxMouse 
Meox1 MeoxMouse 
Meox2 MeoxMouse 
Mnx1 MnxMouse 
Msx1 MsxMouse 
Msx2 MsxMouse 
Msx3 MsxMouse 
Nanog NanogMouse 
NanogPaNanog pseudogene aNanogMouse 
NanogPbNanog pseudogene bNanogMouse 
Nkx1-1 Nk1Mouse 
Nkx1-2 Nk1Mouse 
Nkx2-1 Nk2.1Mouse 
Nkx2-2 Nk2.2Mouse 
Nkx2-3 Nk4Mouse 
Nkx2-4 Nk2.1Mouse 
Nkx2-5 Nk4Mouse 
Nkx2-6 Nk4Mouse 
Nkx2-9 Nk2.2Mouse 
Nkx3-1 Nk3Mouse 
Nkx3-2 Nk3Mouse 
Nkx6-1 Nk6Mouse 
Nkx6-2 Nk6Mouse 
Nkx6-3 Nk6Mouse 
Noto NotoMouse 
Pdx1 PdxMouse 
Tlx1 TlxMouse 
Tlx2 TlxMouse 
Tlx3 TlxMouse 
Vax1 VaxMouse 
Vax2 VaxMouse