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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(3)Gbx(2)Gsx(2)Hox1(4)Hox2(2)Hox3(5)Hox4(4)Hox5(4)Hox6-8(8)
Hox9-13(15)(24)Meox(3)Mnx(3)Pdx(1)       
NKL subclass
Barhl(3)Barx(2)Bsx(1)Dbx(3)Dlx(8)Emx(3)En(4)Hhex(1)Hlx(1)Lbx(3)
Msx(5)Nk1(2)Nk2.1(3)Nk2.2(3)Nk3(3)Nk4(3)Nk5/Hmx(5)Nk6(3)Noto(1)Tlx(4)
Vax(2)Ventx(1)         
 
Loci in ANTP of Zebrafish back to top..
Symbol/LocusNameFamilyOrganismRegulator
barhl1.1BarH-like 1.1BarhlZebrafish 
barhl1.2BarH-like 1.2BarhlZebrafish 
barhl2BarH-like 2BarhlZebrafish 
barx1BarH-like homeobox 1BarxZebrafish 
barx2BarH-like homeobox 2BarxZebrafish 
bsxbrain specific homeoboxBsxZebrafish 
cdx1acaudal type homeo box transcription factor 1 aCdxZebrafish 
cdx1bcaudal type homeobox 1 bCdxZebrafish 
cdx4caudal type homeo box transcription factor 4CdxZebrafish 
dbx1adeveloping brain homeobox 1aDbxZebrafish 
dbx1bdeveloping brain homeobox 1bDbxZebrafish 
dbx2developing brain homeobox 2DbxZebrafish 
dlx1adistal-less homeobox gene 1aDlxZebrafish 
dlx2adistal-less homeobox gene 2aDlxZebrafish 
dlx2bdistal-less homeobox gene 2bDlxZebrafish 
dlx3bdistal-less homeobox gene 3bDlxZebrafish 
dlx4adistal-less homeobox gene 4aDlxZebrafish 
dlx4bdistal-less homeobox gene 4bDlxZebrafish 
dlx5adistal-less homeobox gene 5aDlxZebrafish 
dlx6adistal-less homeobox gene 6aDlxZebrafish 
emx1empty spiracles homeobox 1EmxZebrafish 
emx2empty spiracles homeobox 2EmxZebrafish 
emx3empty spiracles homeobox 3EmxZebrafish 
eng1aengrailed 1aEnZebrafish 
eng1bengrailed 1bEnZebrafish 
eng2aengrailed 2aEnZebrafish 
eng2bengrailed 2bEnZebrafish 
eve1even-skipped-like1EvxZebrafish 
evx1even-skipped homeobox 1EvxZebrafish 
evx2even-skipped homeobox 2EvxZebrafish 
flhfloating headNotoZebrafish 
gbx1gastrulation brain homeobox 1GbxZebrafish 
gbx2gastrulation brain homeo box 2GbxZebrafish 
gsx1GS homeobox 1GsxZebrafish 
gsx2GS homeobox 2GsxZebrafish 
hhexhematopoietically expressed homeoboxHhexZebrafish 
hlx1H2.0-like homeo box 1HlxZebrafish 
hlxb9lahomeo box HB9 like aMnxZebrafish 
hlxb9lbhomeo box HB9 like bMnxZebrafish 
hmx1H6 homeo box 1Nk5/HmxZebrafish 
hmx2H6 family homeobox 2Nk5/HmxZebrafish 
hmx3homeo box (H6 family) 3Nk5/HmxZebrafish 
hmx4H6 family homeobox 4Nk5/HmxZebrafish 
hoxa10aphomeo box A10a, pseudogeneHox9-13(15)Zebrafish 
hoxa10bhomeo box A10bHox9-13(15)Zebrafish 
hoxa11ahomeo box A11aHox9-13(15)Zebrafish 
hoxa11bhomeo box A11bHox9-13(15)Zebrafish 
hoxa13ahomeo box A13aHox9-13(15)Zebrafish 
hoxa13bhomeo box A13bHox9-13(15)Zebrafish 
hoxa1ahomeo box A1aHox1Zebrafish 
hoxa2bhomeo box A2bHox2Zebrafish 
hoxa3ahomeo box A3Hox3Zebrafish 
hoxa3apsi:busm1-227p06.3pHox3Zebrafish 
hoxa4ahomeo box A4aHox4Zebrafish 
hoxa5ahomeo box A5aHox5Zebrafish 
hoxa9ahomeo box A9aHox9-13(15)Zebrafish 
hoxa9bhomeo box A9bHox9-13(15)Zebrafish 
hoxb10ahomeo box B10aHox9-13(15)Zebrafish 
hoxb13ahomeo box B13aHox9-13(15)Zebrafish 
hoxb1ahomeo box B1aHox1Zebrafishdre-mir-10a
hoxb1bhomeo box B1bHox1Zebrafish 
hoxb2ahomeo box B2aHox2Zebrafish 
hoxb3ahomeo box B3aHox3Zebrafishdre-mir-10a
hoxb4ahomeo box B4aHox4Zebrafish 
hoxb5ahomeo box B5aHox5Zebrafish 
hoxb5bhomeo box B5bHox5Zebrafish 
hoxb6ahomeo box B6aHox6-8Zebrafish 
hoxb6bhomeo box B6bHox6-8Zebrafish 
hoxb7ahomeo box B7aHox6-8Zebrafish 
hoxb8ahomeo box B8aHox6-8Zebrafish 
hoxb8bhomeo box B8bHox6-8Zebrafish 
hoxb9ahomeo box B9aHox9-13(15)Zebrafish 
hoxc10ahomeobox protein Hox-C10a-likeHox9-13(15)Zebrafish 
hoxc11ahomeo box C11aHox9-13(15)Zebrafish 
Hoxc11bhomeo box C11bHox9-13(15)Zebrafish 
hoxc12ahomeo box C12aHox9-13(15)Zebrafish 
hoxc12bhomeo box C12bHox9-13(15)Zebrafish 
hoxc13ahomeo box C13aHox9-13(15)Zebrafish 
hoxc13bhomeo box C13bHox9-13(15)Zebrafish 
hoxc1ahomeo box C1aHox1Zebrafish 
hoxc3ahomeo box C3aHox3Zebrafish 
hoxc4ahomeo box C4aHox4Zebrafish 
hoxc5ahomeo box C5aHox5Zebrafish 
hoxc6ahomeo box C6aHox6-8Zebrafish 
hoxc6bhomeo box C6bHox6-8Zebrafish 
hoxc8ahomeo box C8aHox6-8Zebrafish 
hoxc9ahomeo box C9aHox9-13(15)Zebrafish 
hoxd10ahomeo box D10aHox9-13(15)Zebrafish 
hoxd11ahomeo box D11aHox9-13(15)Zebrafish 
hoxd12ahomeo box D12aHox9-13(15)Zebrafish 
hoxd13ahomeo box D13aHox9-13(15)Zebrafish 
hoxd3ahomeo box D3aHox3Zebrafish 
hoxd4ahomeo box D4aHox4Zebrafish 
hoxd9ahomeo box D9aHox9-13(15)Zebrafish 
lbx1aladybird homeobox 1aLbxZebrafish 
lbx1bladybird homeobox 1bLbxZebrafish 
lbx2ladybird homeobox homolog 2LbxZebrafish 
LOC100008066T-cell leukemia, homeobox 3b-likeTlxZebrafish 
LOC100333298Homeobox protein HMX3-likeNk5/HmxZebrafish 
LOC556898mesenchyme homeobox 2-likeMeoxZebrafish 
LOC566969similar to MOX-2 proteinMeoxZebrafish 
meox1mesenchyme homeobox 1MeoxZebrafish 
mnx1motor neuron and pancreas homeobox 1MnxZebrafish 
msxamuscle segment homeobox AMsxZebrafish 
msxbmuscle segment homeobox BMsxZebrafish 
msxcmuscle segment homeobox CMsxZebrafish 
msxdmuscle segment homeobox DMsxZebrafish 
msxemuscle segment homeobox EMsxZebrafish 
nkx1.2laNK1 transcription factor related 2-like,aNk1Zebrafish 
nkx1.2lbNK1 transcription factor related 2-like,bNk1Zebrafish 
nkx2.1aNK2 homeobox 1aNk2.1Zebrafish 
nkx2.1bNK2 homeobox 1bNk2.1Zebrafish 
nkx2.1c Nk2.1Zebrafish 
nkx2.2aNK2 transcription factor related 2aNk2.2Zebrafish 
nkx2.2bNK2 transcription factor related 2bNk2.2Zebrafish 
nkx2.3NK2 transcription factor related 3Nk4Zebrafish 
nkx2.5NK2 transcription factor related 5Nk4Zebrafish 
nkx2.7NK2 transcription factor related 7Nk4Zebrafish 
nkx2.9NK2 transcription factor related, locus 9Nk2.2Zebrafish 
nkx3-1NK3 homeobox 1Nk3Zebrafish 
nkx3.2NK3 homeobox 2Nk3Zebrafish 
nkx3.3NK3 homeobox 3Nk3Zebrafish 
nkx6.1NK6 transcription factor related, locus 1Nk6Zebrafish 
nkx6.2NK6 transcription factor related, locus 2Nk6Zebrafish 
nkx6.3NK6 homeobox 3Nk6Zebrafish 
pdx1pancreatic and duodenal homeobox 1PdxZebrafish 
tlx1T-cell leukemia, homeobox 1TlxZebrafish 
tlx2T-cell leukemia, homeobox 2TlxZebrafish 
tlx3bT-cell leukemia, homeobox 3bTlxZebrafish 
vax1ventral anterior homeobox 1VaxZebrafish 
vax2ventral anterior homeobox 2VaxZebrafish 
zgc:193933zgc:193933VentxZebrafish