Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

CERS Class
Families List  Genes List
The CERS (or LASS) homeobox gene class is highly unusual and encodes proteins that seem to be transmembrane in nature (Mizutani and Kihara 2005; Pewzner-Jung et al. 2006). The function of the homeodomain in these proteins is unknown. There are six CERS (ceramide synthase) genes in the human genome, but only five of these include a homeobox sequence and are therefore included in the CERS homeobox gene class (Holland et al. 2007). Amphioxus has a single CERS homeobox gene.

Reference(s):
Mizutani Y, Kihara A, Igarashi Y (2005) Biochem J 2005, 390:263-271.
Pewzner-Jung Y, Ben-Dor S, Futerman AH (2006) J Biol Chem 281:25001-25005.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class CERS :
Cers(5)         
 
Loci in CERS of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
CERS2ceramide synthase 2CersHuman 
CERS3ceramide synthase 3CersHuman 
CERS4ceramide synthase 4CersHuman 
CERS5ceramide synthase 5CersHuman 
CERS6ceramide synthase 6CersHuman