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POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Families List of Class POU :
Loci in POU of Frog back to top..
hdxhighly divergent homeobox HdxFrog 
oct25POU class V protein oct-25Pou3Frog 
oct60POU class V protein oct-60Pou3Frog 
pou1f1POU class 1 homeobox 1 Pou1Frog 
pou2f1POU class 2 homeobox 1 Pou2Frog 
pou2f3POU class 2 homeobox 3Pou2Frog 
pou3f1POU class 3 homeobox 1 Pou3Frog 
pou3f1bPOU class 3 homeobox 1 Pou3Frog 
pou3f2 Pou3Frog 
pou3f3POU class 3 homeobox 3Pou3Frog 
pou3f4POU class 3 homeobox 4 Pou3Frog 
pou4f1POU class 4 homeobox 1 Pou4Frog 
pou4f1.2POU class 4 homeobox 1Pou4Frog 
pou4f2POU class 4 homeobox 2Pou4Frog 
pou4f3POU class 4 homeobox 3 Pou4Frog 
pou5f1 Pou3Frog 
pou6f1POU class 6 homeobox 1Pou6Frog 
pou6f1b Pou6Frog 
pou6f2POU class 6 homeobox 2 Pou6Frog