Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Reference(s):
Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class POU :
Hdx(1)Pou1(1)Pou2(3)Pou3(4)Pou4(3)Pou5(2)Pou6(2)   
 
Loci in POU of Mouse back to top..
Symbol/LocusNameFamilyOrganismRegulator
Hdx HdxMouse 
Pou1f1 Pou1Mouse 
Pou2f1 Pou2Mouse 
Pou2f2 Pou2Mouse 
Pou2f3 Pou2Mouse 
Pou3f1 Pou3Mouse 
Pou3f2 Pou3Mouse 
Pou3f3 Pou3Mouse 
Pou3f4 Pou3Mouse 
Pou4f1 Pou4Mouse 
Pou4f2 Pou4Mouse 
Pou4f3 Pou4Mouse 
Pou5f1 Pou5Mouse 
Pou5f2 Pou5Mouse 
Pou6f1 Pou6Mouse 
Pou6f2 Pou6Mouse