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TALE Class
Families List  Genes List
Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Atale(1)Irx(44)Meis(23)Mkx(8)Pbx(29)Pknox(14)Tgif(28)   
 
Loci in TALE of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
irx1airoquois homeobox protein 1, aIrxZebrafish 
irx1biroquois homeobox protein 1, bIrxZebrafish 
irx2airoquois homeobox protein 2, aIrxZebrafish 
irx3airoquois homeobox protein 3aIrxZebrafish 
irx3biroquois homeobox protein 3bIrxZebrafish 
irx4airoquois homeobox protein 4aIrxZebrafish 
irx4biroquois homeobox protein 4bIrxZebrafish 
irx5airoquois homeobox protein 5aIrxZebrafish 
irx5biroquois homeobox protein 5bIrxZebrafish 
irx6airoquois homeobox protein 6aIrxZebrafish 
irx7iroquois homeobox protein 7IrxZebrafish 
meis1myeloid ecotropic viral integration 1MeisZebrafish 
meis2.1myeloid ecotropic viral integration site 2.1MeisZebrafish 
meis2.2myeloid ecotropic viral integration site 2.2MeisZebrafish 
meis3myeloid ecotropic viral integration site 3MeisZebrafish 
meis4.1amyeloid ecotropic viral integration site 4.1aMeisZebrafish 
mkxamohawk homeobox aMkxZebrafish 
Pbx-lPbx likePbxZebrafish 
pbx1apre-B-cell leukemia transcription factor 1aPbxZebrafish 
pbx2pre-B-cell leukemia transcription factor 2PbxZebrafish 
pbx3apre-B-cell leukemia transcription factor 3aPbxZebrafish 
pbx3bpre-B-cell leukemia transcription factor 3bPbxZebrafish 
pbx4pre-B-cell leukemia transcription factor 4PbxZebrafish 
pknox1.1pbx/knotted 1 homeobox 1.1PknoxZebrafish 
pknox1.2pbx/knotted 1 homeobox 1.2PknoxZebrafish 
pknox1.3homeobox protein PKNOX1-likePknoxZebrafish 
pknox2pbx/knotted 1 homeobox 2PknoxZebrafish 
tgif1TGFB-induced factor homeobox 1TgifZebrafish 
Tgif2homeobox protein TGIF2-likeTgifZebrafish 
ceh-20C. Elegans Homeobox 20PbxNematode 
ceh-40C. Elegans Homeobox 20PbxNematode 
ceh-60C. Elegans Homeobox 60PbxNematode 
irx-1IRoquois subclass of homeoboX 1IrxNematode 
unc-62UNCoordinated 62MeisNematode 
Gm12605 TgifMouse 
Gm7148 TgifMouse 
Irx1 IrxMouse 
Irx2 IrxMouse 
Irx3 IrxMouse 
Irx4 IrxMouse 
Irx5 IrxMouse 
Irx6 IrxMouse 
Meis1 MeisMouse 
Meis2 MeisMouse 
Meis3 MeisMouse 
Mkx MkxMouse 
Pbx1 PbxMouse 
Pbx2 PbxMouse 
Pbx3 PbxMouse 
Pbx4 PbxMouse 
Pknox1 PknoxMouse 
Pknox2 PknoxMouse 
Tgif1 TgifMouse 
Tgif1p1 TgifMouse 
Tgif2 TgifMouse 
Tgif2lx1 TgifMouse 
Tgif2lx2 TgifMouse 
IRX1iroquois homeobox protein 1IrxHuman 
IRX1P1iroquois homeobox 1 pseudogene 1IrxHuman 
IRX2iroquois homeobox protein 2IrxHuman 
IRX3iroquois homeobox protein 3IrxHuman 
IRX4iroquois homeobox protein 4IrxHuman 
IRX4P1iroquois homeobox 4 pseudogene 1IrxHuman 
IRX5iroquois homeobox protein 5IrxHuman 
IRX6iroquois homeobox protein 6IrxHuman 
MEIS1Meis homeobox 1MeisHumanhsa-mir-155
MEIS2Meis homeobox 2MeisHuman 
MEIS3Meis homeobox 3MeisHuman 
MEIS3P1Meis homeobox 3 pseudogene 1MeisHuman 
MEIS3P2Meis homeobox 3 pseudogene 2MeisHuman 
MKXmohawk homeoboxMkxHuman 
PBX1pre-B-cell leukemia homeobox 1PbxHuman 
PBX2pre-B-cell leukemia homeobox 2PbxHuman 
PBX2P1pre-B-cell leukemia homeobox 2 pseudogene 1PbxHuman 
PBX3pre-B-cell leukemia homeobox 3PbxHuman 
PBX4pre-B-cell leukemia homeobox 4PbxHuman 
PKNOX1PBX/knotted 1 homeobox 1PknoxHuman 
PKNOX2PBX/knotted 1 homeobox 2PknoxHuman 
TGIF1TGFB-induced factor homeobox 1TgifHuman 
TGIF1P1TGFB-induced factor homeobox 1 pseudogene 1TgifHuman 
TGIF2TGFB-induced factor 2 (TALE family homeobox)TgifHuman 
TGIF2LXTGFB-induced factor 2-like, X-linkedTgifHuman 
TGIF2LYTGFB-induced factor 2-like, Y-linkedTgifHuman 
TGIF2P1TGFB-induced factor homeobox 2 pseudogene 1TgifHuman 
TGIF2P2TGFB-induced factor homeobox 2 pseudogene 2TgifHuman 
TGIF2P3TGFB-induced factor homeobox 2 pseudogene 3TgifHuman 
TGIF2P4TGFB-induced factor homeobox 2 pseudogene 4TgifHuman 
AraAraucanIrxHoneybee 
ExdExtradenticlePbxHoneybee 
HthHomothoraxMeisHoneybee 
MirrMirrorIrxHoneybee 
PknoxPknoxPknoxHoneybee 
TgifTgifTgifHoneybee 
achiachintyaTgifFruitfly 
araaraucanIrxFruitfly 
caupcaupolicanIrxFruitfly 
CG11617CG11617MkxFruitfly 
exdextradenticlePbxFruitfly 
hthhomothoraxMeisFruitfly 
mirrmirrorIrxFruitfly 
visvismayTgifFruitfly 
irx1iroquois homeobox 1 IrxFrog 
irx2iroquois homeobox 2IrxFrog 
irx3iroquois homeobox 3IrxFrog 
irx4iroquois homeobox 4 IrxFrog 
irx5iroquois homeobox 5IrxFrog 
irx6iroquois homeobox 6IrxFrog 
meis1Meis homeobox 1 MeisFrog 
meis2Meis homeobox 2 MeisFrog 
meis3Meis homeobox 3MeisFrog 
mkxmohawk homeobox MkxFrog 
pbx1pre-B-cell leukemia homeobox 1 PbxFrog 
pbx2pre-B-cell leukemia homeobox 2 PbxFrog 
pbx3pre-B-cell leukemia homeobox 3 PbxFrog 
pknox2PBX/knotted 1 homeobox 2 PknoxFrog 
tgif1TGFB-induced factor homeobox 1TgifFrog 
tgif2TGFB-induced factor homeobox 2TgifFrog 
IRX2iroquois homeobox 2IrxChicken 
IRX5iroquois homeobox 5IrxChicken 
LOC428131TGIF likeTgifChicken 
MEIS1Meis homeobox 1MeisChicken 
MEIS2Meis homeobox 2MeisChicken 
MKXmohawk homeoboxMkxChicken 
Pbx-lPbx likePbxChicken 
PBX1pre-B-cell leukemia homeobox 1PbxChicken 
Pbx2-lPbx2 likePbxChicken 
PBX3pre-B-cell leukemia homeobox 3PbxChicken 
PKNOX1PBX/knotted 1 homeobox 1PknoxChicken 
PKNOX2PBX/knotted 1 homeobox 2PknoxChicken 
TGIF1TGFB-induced factor homeobox 1TgifChicken 
AraAraucanIrxBeetle 
ExdExtradenticlePbxBeetle 
HthHomothoraxMeisBeetle 
MirrMirrorIrxBeetle 
MkxMohawkMkxBeetle 
PknoxPknoxPknoxBeetle 
Tgif1Tgif1TgifBeetle 
Tgif2Tgif2TgifBeetle 
AtaleAtaleAtaleAmphioxus 
IrxAIrxAIrxAmphioxus 
IrxB1IrxB1IrxAmphioxus 
IrxB2IrxB2IrxAmphioxus 
MeisMeisMeisAmphioxus 
MkxMkxMkxAmphioxus 
PbxPbxPbxAmphioxus 
PknoxPknoxPknoxAmphioxus 
TgifTgifTgifAmphioxus