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TALE Class
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Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(2)Meis(2)Mkx(1)Pbx(4)Pknox(2)Tgif(2)    
 
Loci in TALE of Chicken back to top..
Symbol/LocusNameFamilyOrganismRegulator
IRX2iroquois homeobox 2IrxChicken 
IRX5iroquois homeobox 5IrxChicken 
LOC428131TGIF likeTgifChicken 
MEIS1Meis homeobox 1MeisChicken 
MEIS2Meis homeobox 2MeisChicken 
MKXmohawk homeoboxMkxChicken 
Pbx-lPbx likePbxChicken 
PBX1pre-B-cell leukemia homeobox 1PbxChicken 
Pbx2-lPbx2 likePbxChicken 
PBX3pre-B-cell leukemia homeobox 3PbxChicken 
PKNOX1PBX/knotted 1 homeobox 1PknoxChicken 
PKNOX2PBX/knotted 1 homeobox 2PknoxChicken 
TGIF1TGFB-induced factor homeobox 1TgifChicken