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TALE Class
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Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(6)Meis(3)Mkx(1)Pbx(3)Pknox(1)Tgif(2)    
 
Loci in TALE of Frog back to top..
Symbol/LocusNameFamilyOrganismRegulator
irx1iroquois homeobox 1 IrxFrog 
irx2iroquois homeobox 2IrxFrog 
irx3iroquois homeobox 3IrxFrog 
irx4iroquois homeobox 4 IrxFrog 
irx5iroquois homeobox 5IrxFrog 
irx6iroquois homeobox 6IrxFrog 
meis1Meis homeobox 1 MeisFrog 
meis2Meis homeobox 2 MeisFrog 
meis3Meis homeobox 3MeisFrog 
mkxmohawk homeobox MkxFrog 
pbx1pre-B-cell leukemia homeobox 1 PbxFrog 
pbx2pre-B-cell leukemia homeobox 2 PbxFrog 
pbx3pre-B-cell leukemia homeobox 3 PbxFrog 
pknox2PBX/knotted 1 homeobox 2 PknoxFrog 
tgif1TGFB-induced factor homeobox 1TgifFrog 
tgif2TGFB-induced factor homeobox 2TgifFrog