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TALE Class
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Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(8)Meis(5)Mkx(1)Pbx(5)Pknox(2)Tgif(9)    
 
Loci in TALE of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
IRX1iroquois homeobox protein 1IrxHuman 
IRX1P1iroquois homeobox 1 pseudogene 1IrxHuman 
IRX2iroquois homeobox protein 2IrxHuman 
IRX3iroquois homeobox protein 3IrxHuman 
IRX4iroquois homeobox protein 4IrxHuman 
IRX4P1iroquois homeobox 4 pseudogene 1IrxHuman 
IRX5iroquois homeobox protein 5IrxHuman 
IRX6iroquois homeobox protein 6IrxHuman 
MEIS1Meis homeobox 1MeisHumanhsa-mir-155
MEIS2Meis homeobox 2MeisHuman 
MEIS3Meis homeobox 3MeisHuman 
MEIS3P1Meis homeobox 3 pseudogene 1MeisHuman 
MEIS3P2Meis homeobox 3 pseudogene 2MeisHuman 
MKXmohawk homeoboxMkxHuman 
PBX1pre-B-cell leukemia homeobox 1PbxHuman 
PBX2pre-B-cell leukemia homeobox 2PbxHuman 
PBX2P1pre-B-cell leukemia homeobox 2 pseudogene 1PbxHuman 
PBX3pre-B-cell leukemia homeobox 3PbxHuman 
PBX4pre-B-cell leukemia homeobox 4PbxHuman 
PKNOX1PBX/knotted 1 homeobox 1PknoxHuman 
PKNOX2PBX/knotted 1 homeobox 2PknoxHuman 
TGIF1TGFB-induced factor homeobox 1TgifHuman 
TGIF1P1TGFB-induced factor homeobox 1 pseudogene 1TgifHuman 
TGIF2TGFB-induced factor 2 (TALE family homeobox)TgifHuman 
TGIF2LXTGFB-induced factor 2-like, X-linkedTgifHuman 
TGIF2LYTGFB-induced factor 2-like, Y-linkedTgifHuman 
TGIF2P1TGFB-induced factor homeobox 2 pseudogene 1TgifHuman 
TGIF2P2TGFB-induced factor homeobox 2 pseudogene 2TgifHuman 
TGIF2P3TGFB-induced factor homeobox 2 pseudogene 3TgifHuman 
TGIF2P4TGFB-induced factor homeobox 2 pseudogene 4TgifHuman