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TALE Class
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Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(6)Meis(3)Mkx(1)Pbx(4)Pknox(2)Tgif(7)    
 
Loci in TALE of Mouse back to top..
Symbol/LocusNameFamilyOrganismRegulator
Gm12605 TgifMouse 
Gm7148 TgifMouse 
Irx1 IrxMouse 
Irx2 IrxMouse 
Irx3 IrxMouse 
Irx4 IrxMouse 
Irx5 IrxMouse 
Irx6 IrxMouse 
Meis1 MeisMouse 
Meis2 MeisMouse 
Meis3 MeisMouse 
Mkx MkxMouse 
Pbx1 PbxMouse 
Pbx2 PbxMouse 
Pbx3 PbxMouse 
Pbx4 PbxMouse 
Pknox1 PknoxMouse 
Pknox2 PknoxMouse 
Tgif1 TgifMouse 
Tgif1p1 TgifMouse 
Tgif2 TgifMouse 
Tgif2lx1 TgifMouse 
Tgif2lx2 TgifMouse