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TALE Class
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Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(1)Meis(1)Pbx(3)       
 
Loci in TALE of Nematode back to top..
Symbol/LocusNameFamilyOrganismRegulator
ceh-20C. Elegans Homeobox 20PbxNematode 
ceh-40C. Elegans Homeobox 20PbxNematode 
ceh-60C. Elegans Homeobox 60PbxNematode 
irx-1IRoquois subclass of homeoboX 1IrxNematode 
unc-62UNCoordinated 62MeisNematode