Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

ZF Class
Families List  Genes List
Genes in the ZF (zinc finger) class encode proteins with zinc finger motifs in addition to one or more homeodomains. There are 14 members of the ZF homeobox gene class in the human genome (plus one pseudogene), which can be divided into five distinct gene families. There are many additional zinc finger-containing genes in the human genome that do not contain homeobox sequences; these are not included in the ZF homeobox gene class. As argued by Holland et al. (2007), it is logical to include the HOMEZ gene in the ZF class, even though it does not encode zinc fingers, because its homeodomain sequences are clearly related to those encoded by some of the ZF genes. Amphioxus has five ZF-class genes.

Reference(s):
Bayarsaihan D et al. (2003) , Proc Natl Acad Sci USA 100:10358-10363.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ZF :
Adnp(2)Tshz(3)Zeb(3)Zfhx(3)Zhx/Homez(4)     
 
Loci in ZF of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
ADNPactivity-dependent neuroprotector homeoboxAdnpHuman 
ADNP2ADNP homeobox 2AdnpHuman 
HOMEZhomeobox and leucine zipper encodingZhx/HomezHuman 
TSHZ1teashirt zinc finger homeobox 1TshzHuman 
TSHZ2teashirt zinc finger homeobox 2TshzHuman 
TSHZ3teashirt zinc finger homeobox 3TshzHuman 
ZEB1zinc finger E-box binding homeobox 1ZebHumanhsa-mir-200a; hsa-mir-200b; hsa-mir-205
ZEB2zinc finger E-box binding homeobox 2ZebHumanhsa-mir-138; hsa-mir-200a; hsa-mir-200b; hsa-mir-205; hsa-mir-221
ZEB2P1zinc finger E-box binding homeobox 2 pseudogene 1ZebHuman 
ZFHX2zinc finger homeobox 2ZfhxHuman 
ZFHX3zinc finger homeobox 3ZfhxHuman 
ZFHX4zinc finger homeobox 4ZfhxHuman 
ZHX1zinc fingers and homeoboxes 1Zhx/HomezHuman 
ZHX2zinc fingers and homeoboxes 2Zhx/HomezHuman 
ZHX3zinc fingers and homeoboxes 2Zhx/HomezHuman